Digital implementation of cancer care is increasingly common, with research indicating encouraging results for feasibility of implementation and efficacy in improving outcomes for consumers. However, consumers with lower levels of health literacy or digital health literacy may face additional challenges when accessing health care via digital platforms, compared with other consumers. As groups with lower levels of health/digital health literacy overlap with populations experiencing poorer cancer outcomes, implementation of digital health applications in cancer care may therefore miss those most in need of improved care and may widen disparities in outcomes between these groups and those with higher levels of health/digital health literacy. This presentation will outline (a) components of health literacy, digital health literacy, and digital inclusion (b) population groups who are more likely to experience challenges with health literacy, digital health literacy, and digital inclusion, and how these overlap with populations experiencing poorer access to care and poorer outcomes and (c) current research aiming to examine the impact of socioeconomic circumstances and digital health literacy on digital health engagement in people with cancer, and to determine ways in which access to cancer care resources, particularly via digital health applications, can be better supported for people living with cancer in socioeconomically and/or geographically disadvantaged circumstances. Results of mixed methods and qualitative studies indicating the impact of employment experience, education, income level, social support and geography in impacting on digital health literacy and engagement will be reported. Finally, this presentation will outline potential solutions to overcome some of these challenges in relation to implementation of digital health applications in cancer care.