Inflammation is a hallmark of cancer and is linked to worse prognosis and side-effects such as depression, worse stress-coping ability, cognitive impairment, and peripheral neuropathy. This has led to attempts to develop anti-inflammatory interventions for these symptoms. One factor that can alter inflammatory responses and impair immune function is circadian disruption, which is also associated with cancer. However, there remains a limited understanding of how circadian disruption modulates cancer-induced inflammation, making it difficult to ascertain if anti-inflammatory strategies designed to treat cancer-related side-effects will be as efficacious in patients with circadian disruption. To explore this, we investigated the effect of circadian disruption on cancer-induced inflammation in an orthotopic mouse breast cancer model. Using a validated chronic jetlag protocol that advances the light-cycle by 8 h every 2 days to disrupt circadian rhythms, we found that circadian disruption alters cancer-induced inflammation in a tissue-specific manner, increasing inflammation in the body and brain while decreasing inflammation within the tumour tissue itself (p < 0.05 for all). Circadian disruption did not affect tumour burden (p > 0.05), suggesting that increased inflammation was not a result of increased cancer progression. Importantly, how cancer-induced inflammation was changed by circadian disruption differed depending on the organ that was investigated. Overall, these findings identify the importance of healthy circadian rhythms for limiting cancer-induced inflammation. Anti-inflammatory interventions designed to treat cancer-related symptoms may require remediation of circadian disruption to be most effective.